论文部分内容阅读
用两种模型研究贻贝多活素((multibioactive substances of Mytilus edulis,MSM)对实验性心肌缺血的保护作用。在结扎冠脉致大鼠急性心肌梗死实验中,MSM(1.35、4.05、6.75g/kg)可明显降低缺血EKG中S-T段异常抬高的程度,ΣST分别为25.2、27.8和21.8mV,与NS对照组(62.9mV)差异非常显著(P<0.001),N-BT染色显示心肌梗死的范围明显缩小。MSM亦能减轻因快速静注垂体后叶素引起的大鼠EKG中缺血性损伤的变化,使心肌缺血阳性率明显降低。结果表明,MSM对实验性心肌缺血有保护作用,其作用机制可能与降低血中MDA浓度,提高CuZn-SOD、GSH-Px活性,防止心肌细胞脂质过氧化作用有关。
Two models were used to study the protective effects of multibioactive substances of Mytilus edulis (MSM) on experimental myocardial ischemia.In the experiment of acute myocardial infarction induced by ligation of coronary artery in rats, MSM (1.35, 4.05, 6.75g) /kg) significantly reduced the elevation of ST-segment abnormality in ischemic EKG. The ΣST was 25.2, 27.8, and 21.8 mV, respectively, which was significantly different from that in the NS control group (62.9 mV) (P<0.001). N-BT staining showed that The scope of myocardial infarction was significantly reduced, and MSM can also reduce the changes of ischemic injury in rat EKG caused by rapid intravenous injection of pituitrin, resulting in a significant reduction in the positive rate of myocardial ischemia.The results show that MSM is lack of experimental myocardial defects. Blood has a protective effect, and its mechanism of action may be related to lowering blood MDA concentration, increasing CuZn-SOD, GSH-Px activity and preventing myocardial cell lipid peroxidation.