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目的：探讨曲马多、布比卡因混合液持续硬膜外腔注入治疗前列腺切除术后疼痛的疗效。方法：选择４０例前列腺增生症（ＢＰＨ）患者，随机分为两组，均于连续硬膜外麻醉下行耻骨上经膀胱前列腺切除术，术后留置硬膜外管４８ｈ。实验组采用曲马多、布比卡因混合液持续硬膜外注入，对照组采用单纯曲马多间断注入。两组曲马多总量一致。观察两组ＶＡＳ测痛评分，膀胱痉挛次数、持续时间，停止冲洗时间等。结果：实验组较对照组具有镇痛效果平稳，膀胱痉挛次数少、持续时间短、发生率低，不良反应少等特点，但术后恢复指标两组无显著性差异。结论：曲马多、布比卡因混合液持续硬膜外腔注药用于前列腺切除术后镇痛，与单纯曲马多硬膜外腔注药相比，具有镇痛效果平稳、不良反应少等优点。
Objective: To investigate the efficacy of tramadol and bupivacaine mixed epidural continuous epidural in the treatment of post-prostatectomy pain. Methods: Forty patients with benign prostatic hyperplasia (BPH) were randomly divided into two groups. All patients underwent suprapubic transvesical prostatectomy under continuous epidural anesthesia. The epidural tube was placed for 48 hours after operation. Experimental group tramadol, bupivacaine mixture continued epidural injection, the control group was injected with tramadol alone. Tramadol in both groups the same amount. Two groups were observed VAS pain score, bladder spasm frequency, duration, stop washing time and so on. Results: Compared with the control group, the experimental group had the characteristics of stable analgesic effect, few bladder spasm, short duration, low incidence and few adverse reactions. However, there was no significant difference between the two groups in the postoperative recovery index. CONCLUSION: Tramadol and bupivacaine combined with continuous epidural injection are used for post-prostatectomy analgesia. Compared with simple tramadol epidural injection, the combination of tramadol and bupivacaine has a stable analgesic effect and adverse reactions Less advantages.