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靛玉红(indirubin)是从中药青黛分离出来的抗癌有效成份,现已成为治疗慢粒有明显疗效的新药。该药虽疗效好,伹少数病例服药后出现恶心、呕吐、大便次数增多等副作用远拘允笛橐卜⑾执蠹亮康牡逵窈煊猩吖费遄泵傅淖饔谩N私徊教教制涠纠碜饔?我们观察了长期口服靛玉红损伤肝细胞的原理,供临床参考。材料与方法取狗口服靛玉红6个月的肝组织(20mg/kg3只,100mg/kg3只,200mg/kg2只;对照2只);大鼠口服靛玉红1个月的肝组织(200mg/kg 4只,对照5只)。一部分肝组织常规石腊切片,H·E 染色,Gordon 和Sweet氏法示网状纤维,钙钴法示碱性磷酸酶(AKP),甲基绿-呱诺咛示核糖核酸(RNA)
The indirubin is an effective anticancer component isolated from the Chinese herbal medicine Qingye. It has now become a new drug for the treatment of chronic granuloma. Although the drug has a good curative effect, after a few cases of nausea, vomiting, increased stool frequency, etc., side effects may cause illness and may cause disability. (11) Executive Kang Liang Kang oysters N 徊 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们 我们? Materials and Methods Six months after oral administration of indirubin, the liver tissues (20mg/kg, 100mg/kg, 2; 200mg/kg; control); Rats were orally administered with Indirubin for 1 month (200mg). /kg 4, control 5). A section of hepatic tissue was routinely paraffin-embedded, stained with H·E, Gordon and Sweet’s method showed reticular fibers, calcium-cobalt method showed alkaline phosphatase (AKP), and methyl green-chromosomal RNA (RNA).