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一、甲苯咪唑(mebendazole) 为苯并咪唑衍生物,能抑制蠕虫对葡萄糖的摄取,导致糖原丢失,从而减少了虫体内ATP合成。本品还可与哺乳动物或线虫的微管蛋白,对虫休和虫卵都百一定毒性。本品口服后,肠道吸收较少,服后2～4小时血浆浓度达峰值,约有5～10％代谢为脱羧基衍生物由尿排出,大部原形药物由粪便排出。临床资料表明,甲苯咪唑为一广谱驱蠕虫药,对鞭虫、钩虫、蛲虫及美洲板口线虫感染有效;故适用于肠道寄生虫混合感染。剂量范围,日服2次(早、晚
First, mebendazole is a benzimidazole derivative, can inhibit the worm’s glucose uptake, leading to the loss of glycogen, thereby reducing the ATP synthesis in vivo. This product can also be with mammalian or nematode tubulin, insect parasite and eggs are certain hundred toxicity. After oral administration, less intestinal absorption, 2 to 4 hours after serving plasma concentration peak, about 5 to 10% of the metabolism of decarboxylated derivatives excreted by the urine, most of the prototype drugs excreted by the feces. Clinical data show that mebendazole is a broad-spectrum antihelminthicides, whipworm, hookworm, pinworm and Ipleana nematode infection is effective; it is suitable for intestinal parasites mixed infection. Dose range, 2 times a day (morning and evening