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目前对胆系严重感染的抗生素治疗,仍存在不少问题。常用的庆大霉素对革兰氏阴性细菌有广谱抗菌作用,但以静滴或肌注给药均不能在胆汁中获得高的有效药物浓度。本研究为寻求新的给药途径,提高抗生素在胆汁中的浓度,采用经脐静脉插管、间隙推注庆大霉素,按时收集胆汁测定药物浓度,并与周围静脉给药对照,结果发现脐静脉推注庆大霉素在胆汁中的浓度是周围静脉给药的两倍以上,并且出现双峰代谢现象。这可能是经脐门脉静脉给庆大霉纱治疗严重肝胆感染获得良效的原因。
Currently there are still many problems with the antibiotic treatment of severe biliary infection. Gentamicin commonly used for gram-negative bacteria have a broad-spectrum antibacterial effect, but intravenous infusion or intramuscular injection can not be obtained in bile high effective drug concentration. In order to find a new route of administration to improve the concentration of antibiotics in the bile, the study was conducted by umbilical vein cannulation, intermittent bolus gentamicin, gallbladder on time to determine the drug concentration, and compared with the surrounding intravenous administration, found that Umbilical intravenous injection of gentamicin in bile concentration is more than twice the intravenous administration, and bimodal metabolic phenomenon. This may be due to the umbilical portal vein to celebrate the fungus yarn treatment of severe liver and gallbladder infection obtained good effect.