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目的:探讨丙氨酰谷氨酰胺(Ala-Gln)在创伤性急性肺损伤(ALI)机械通气治疗中的临床疗效。方法:将创伤性ALI机械通气患者60例随机分为观察组(n=30)和对照组(n=30),观察组在常规治疗基础上加Ala-Gln 0.5 g/(kg·d),连用7 d,比较两组的PaO_2、氧合指数、APACHEⅡ评分、机械通气时间、住ICU时间、ARDS发生率及病死率。结果:观察组治疗后PaO_2、氧合指数、APACHEⅡ评分、机械通气时间、住ICU时间、ARDS发生率组均明显优于对照组(P均<0.05),但病死率无显著性差异(P>0.05)。结论:Ala-Gln在创伤性ALI机械通气治疗中可能有肺保护作用,适合创伤性ALI的治疗。
Objective: To investigate the clinical efficacy of alanyl-glutamine (Ala-Gln) in the treatment of traumatic acute lung injury (ALI). Methods: Sixty patients with traumatic ALI were randomly divided into observation group (n = 30) and control group (n = 30). The observation group was given Ala-Gln 0.5 g / (kg · d) For 7 days, PaO_2, oxygenation index, APACHEⅡscore, mechanical ventilation time, ICU stay time, incidence of ARDS and case fatality were compared between the two groups. Results: The PaO_2, oxygenation index, APACHEⅡscore, mechanical ventilation time, ICU time and ARDS incidence rate in the observation group were significantly better than those in the control group (all P <0.05), but no significant difference was found between the two groups (P> 0.05). Conclusion: Ala-Gln may have lung protection in the treatment of traumatic ALI. It is suitable for the treatment of traumatic ALI.