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目的:探讨微量静脉泵注射呋塞米对重度子痫前期患者的利尿效果。方法:选择需要利尿的重度子痫前期患者40例,将其随机分成实验组及对照组,每组各20例。实验组采用微量静脉泵注射呋塞米,对照组静脉注射呋塞米。观察给予呋塞米后12 h患者尿量及血清钠、钾、氯、肌酐水平的变化,并进行组间比较。同时观察孕妇在治疗过程中有无不良反应。结果:应用呋塞米后6 h内,实验组尿量较对照组少,但差异无统计学意义(P>0.05);之后的6 h内,实验组尿量较对照组多,且差异有统计学差异(P=0.019)。两组治疗前后血清钾、钠、氯、肌酐水平无明显改变(P>0.05)。治疗过程中未发现不良反应。结论:采用微量静脉泵注射呋塞米用于重度子痫前期患者可避免血容量的大幅升降,利尿作用安全、有效。
Objective: To investigate the effect of intravenous furosemide on diuretic in patients with severe preeclampsia. Methods: Forty patients with severe preeclampsia who required diuresis were selected and randomly divided into experimental group and control group with 20 cases in each group. In the experimental group, furosemide was injected by micro-venous pump and furosemide was intravenously injected in the control group. The changes of urinary output, serum sodium, potassium, chloride and creatinine in 12 h after furosemide administration were observed and compared between groups. At the same time observe the pregnant women in the course of treatment with or without adverse reactions. Results: Within 6 hours after the administration of furosemide, the urinary volume in the experimental group was less than that in the control group, but the difference was not statistically significant (P> 0.05). Within 6 hours after the furosemide application, urine volume in the experimental group was more than that in the control group Statistical difference (P = 0.019). Before and after treatment, serum potassium, sodium, chloride and creatinine levels did not change significantly (P> 0.05). No adverse reactions were found during the treatment. Conclusion: The micro-venous injection of furosemide in patients with severe preeclampsia can avoid a sharp rise in blood volume, diuretic effect is safe and effective.