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目的探讨广东人服华法林剂量及疗效、风险。方法将100例患者分为机械瓣膜组和非机械瓣膜房颤组,服华法林以INR比值1·8-2·5范围为依据进行药量升降调节,寻求最佳剂量最小风险。结果两组患者使用华法林剂量差异无统计学意义(P>0·05)。最终获得华法林维持量及出血率亦无统计学意义,在INR比值1·8-2·5范围内高龄患者出血率无明显增加。结论在INR比值1·8-2·5范围内用华法林抗凝治疗的剂量疗效安全可靠,即使有出血均是小量的,患者多能自行处理或请医生对症处理,均可安全度过,无脑部大出血风险。
Objective To investigate the dosage of warfarin in Guangdong and its curative effect and risk. Methods One hundred patients were divided into mechanical valve group and non-mechanical valve atrial fibrillation group. The warfarin dose was adjusted based on the range of INR ratio of 1.8-2.5 to find the minimum risk of optimal dosage. Results There was no significant difference in the dosage of warfarin between the two groups (P> 0.05). The final warfarin maintenance and bleeding rates were also not statistically significant, in the INR ratio of 1.8-2.5 range of elderly patients with no significant increase in bleeding. Conclusion The dose of anticoagulation with warfarin is safe and reliable in the INR range of 1.8-2.5. Even if there is a small amount of bleeding, the patients can handle it safely or symptomatically, No brain bleeding risk.