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Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function,in which fetal liver kinase-1(Flk-1),as a major regulator of vasculogenesis and angiogenesis,plays a very important role.Microvessel density(MVD)was greater in an aged model group compared with the young sham operated group(P < 0.01).MVD and the sum of the lumen area were decreased in the aged group at 1,3,6 and 12 days following ischemia/reperfusion(I/R)injury compared with the young model group(P < 0.05 and P < 0.01,respectively).Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group(P < 0.01).Flk-1 protein and mRNA expression was lower in the aged group at 1,3,6 and 12 days after I/R compared with the young model group(P < 0.01).Flk-1 expression in aged rats attenuated rapidly,but was still maintained at relatively higher levels at 12 days following I/R in younger rats.The results suggest that angiogenesis was weakened after cerebral I/R in aged rats,and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA.