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目的通过Meta分析的方法对不同剂型去氨加压素治疗小儿遗尿症的依从性、疗效和安全性作出评价。方法通过建立文献纳入及排除标准,制定检索策略,检索中国生物医学文献数据库、中国期刊全文数据库、万方数据库、维普中文科技期刊数据库、PubMed、Cochrane图书馆、EMBASE、Elsevier、Springer、EBSCO数据库相关文献,获取不同剂型去氨加压素治疗小儿遗尿症的临床试验研究全文,并对文献质量进行评价,使用软件RevMan 5.0对纳入文献进行Meta分析。从有效性、依从性及不良反应发生率评价不同剂型去氨加压素治疗小儿遗尿症的价值。结果 1.去氨加压素片剂与非片剂治疗小儿遗尿症疗效比较无统计学差异(MD=-0.33,95%CI:-0.68～0.01,P=0.06)。2.去氨加压素舌下含片治疗小儿遗尿症的疗效与采用去氨加压素片剂比较,差异无统计学意义(MD=-0.02,95%CI:-0.31～0.26,P=0.87)。3.去氨加压素舌下含片治疗小儿遗尿症,其依从性显著优于去氨加压素片剂(OR=2.19,95%CI:1.20～4.01,P=0.01)。结论治疗小儿遗尿症的去氨加压素片剂、喷鼻剂和舌下含片3种剂型疗效是相同的,但考虑到儿童的特殊依从性,舌下含片更易为儿童所接受。
Objective To evaluate the compliance, efficacy and safety of different forms of desmopressin in the treatment of childhood enuresis by Meta-analysis. Methods To establish a search strategy based on the inclusion and exclusion of documents, and to search the Chinese Biomedical Literature Database, Chinese Journal Full-text Database, Wanfang Database, VIP Chinese Journal of Science and Technology Database, PubMed, Cochrane Library, EMBASE, Elsevier, Springer, EBSCO database Literature, access to different forms of desmopressin treatment of childhood enuresis clinical trials full text, and to evaluate the quality of the literature, the use of software RevMan 5.0 Meta-analysis of the included literature. Evaluate the value of different doses of desmopressin in the treatment of childhood enuresis based on the validity, compliance and incidence of adverse reactions. Results 1. There was no significant difference in the efficacy of desmopressin tablets versus non-tablets in treating children with enuresis (MD = -0.33, 95% CI: -0.68-0.01, P = 0.06). 2. The desmopressin sublingual tablet treatment of children with enuresis efficacy and desmopressin tablets compared, the difference was not statistically significant (MD = -0.02,95% CI: -0.31 ~ 0.26, P = 0.87). 3. The desmopressin sublingual tablets for treatment of childhood enuresis, its compliance was significantly better than the desmopressin tablets (OR = 2.19,95% CI: 1.20 ~ 4.01, P = 0.01). Conclusions The efficacy of the three formulations of desmopressin, nasal spray and sublingual tablet for the treatment of infantile enuresis is the same, but the sublingual tablet is more acceptable to children considering the special compliance of children.