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目的:探讨加巴喷丁治疗糖尿病痛性神经病变的临床疗效、安全性及相关机制。方法:随机将200例糖尿病痛性神经病变患者分为对照组、观察组;对照组100例给予常规治疗,控制血糖,甲钴胺营养神经,硫辛酸抗氧化应激;观察组100例除给予同对照组的常规治疗外给予加巴喷丁治疗,两组疗程均为2周,测定治疗前、治疗后1周、2周的VAS值(VAS:Visual analogue scale,视觉模拟评分法)的变化,并进行疗效分析。结果:对照组、观察组治疗后疼痛均有一定程度的缓解,总有效率67.0%、80.0%,观察组>对照组,两组间疗效比较,差异有统计学意义(P<0.05)。治疗后两组的VAS评分显著下降,下降幅度观察组>对照组,差异均有统计学意义(P<0.05)。观察组无严重药物不良反应。结论:加巴喷丁治疗糖尿病痛性神经病变有一定效果,安全性好。
Objective: To investigate the clinical efficacy, safety and related mechanisms of gabapentin in the treatment of diabetic pain neuropathy. Methods: 200 patients with diabetic neuropathic pain were randomly divided into control group and observation group. 100 cases in control group were given routine treatment to control blood glucose, mecobalamin nutritional nerve and lipoic acid, Gabapentin was given to the patients outside the control group. The course of treatment was 2 weeks. The changes of VAS (visual analogue scale) before and after treatment for 1 week and 2 weeks after treatment were measured and compared Efficacy analysis. Results: The pain of the control group and the observation group were relieved to a certain degree after treatment, with the total effective rate of 67.0% and 80.0%. The observation group and the control group showed significant differences in the curative effect between the two groups (P <0.05). After treatment, the VAS score decreased significantly in both groups, and the difference between the observation group and the control group was statistically significant (P <0.05). Observation group no serious adverse drug reactions. Conclusion: Gabapentin has some effect on treating diabetic neuropathic pain and has good safety.