A novel p-acetaminophen resin(named as GQ-1) was synthesized with chloromethylated polystyrene and p-acetaminophen.It can be used without any wetting process.The objective of this work was to study the adsorption performances for vanillin onto GQ-1 with two kinds of the hydrogen bond site of acetamino group and hydroxyl group.The results showed that the adsorption property of vanillin onto GQ-1 was superior to XAD-4,H103,NDA150,and NDA88.The adsorption capacity of vanillin onto GQ-1 is not greatly discrepant until the solution pH is higher than 5.31.The saturated adsorption quantity of vanillin was up to 141.32 mg/mL(wet resin) according to the dynamic adsorption and desorption experiments at 293 K.The resin could be regenerated by 7 BV ethanol. A novel p-acetaminophen resin (named as GQ-1) was synthesized with chloromethylated polystyrene and p-acetaminophen. It can be used without any wetting process. The objective of this work was to study the adsorption performances for vanillin onto GQ-1 with two kinds of the hydrogen bond site of acetamino group and hydroxyl group. The results showed that the adsorption property of vanillin onto GQ-1 was superior to XAD-4, H103, NDA150, and NDA88. The adsorption capacity of vanillin onto GQ-1 is not greatly discrepant until the solution pH is higher than 5.31. The saturated adsorption quantity of vanillin was up to 141.32 mg / mL (wet resin) according to the dynamic adsorption and desorption experiments at 293 K. The resin could be regenerated by 7 BV ethanol.