间质性肺部疾病(ILD)是以肺泡壁为主要病变所引起的众多异质性疾病组成的疾病谱[1],其病理主要表现为早期弥漫性肺泡炎及后期大量间质细胞增生、基质胶原进行性聚集以致取代正常的肺组织结构,严重影响肺的通气和换气功能,最终导致呼吸功能衰竭而死亡,其发病机理未完全阐明,目前 Interstitial lung disease (ILD) is a disease spectrum composed of many heterogeneous diseases caused by the alveolar wall as the main disease [1]. The pathological manifestations include diffuse alveolitis in the early stage and massive interstitial cell proliferation in the later stage, The matrix collagen is aggregated so as to replace the normal lung tissue structure and seriously affect the ventilation and ventilation functions of the lungs, which eventually leads to respiratory failure and death. The pathogenesis of this phenomenon is not completely elucidated. At present,