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肥胖是发生高血压的独立危险因素。现已证实肥胖相关的高血压的发病和维持是通过体液调节机制实现的,激素、细胞因子、生物活性肽等通过循环激素、自分泌、旁分泌及细胞内分泌的方式调节着代谢、食欲和血压。脂肪分泌的多种体液因子瘦素、脂联素、抵抗素、脂肪RAS等,以及其它体液因子ghrelin,肽YY,增食因子等,在肥胖相关的高血压的发病过程中起着重要作用。深入研究它们在食欲和代谢方面的调节机制,可为肥胖相关高血压的治疗提供新靶点。
Obesity is an independent risk factor for developing hypertension. It has been confirmed that the pathogenesis and maintenance of obesity-related hypertension are achieved through the humoral regulation mechanism. Hormones, cytokines, bioactive peptides and the like regulate metabolism, appetite and blood pressure by means of circulating hormones, autocrine, paracrine and cellular endocrine . Fat secretion of a variety of humoral factors leptin, adiponectin, resistin, fat RAS, as well as other humoral factors ghrelin, peptide YY, dietary factors, play an important role in the pathogenesis of obesity-related hypertension. In-depth study of their regulation of appetite and metabolism, can provide a new target for the treatment of obesity-related hypertension.