Background:Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury (AKI) in severely injured patients admitted to the Intensive Care Unit (ICU) for whom creatine kinase (CK) levels were available.Methods:For this retrospective observational study,we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili (FVL) University Hospital.Our primary outcome was the incidence of AKI.Multivariate regression analysis was used to assess risk factors for this outcome.Results:A total of 315 patients were included.The trauma mechanisms were blunt (n=130),penetrating (n=66) and blast (n=44) trauma.The median[interquartile range,IQR) of injury severity score (ISS) was 21 (16-39).AKI developed in 75 patients (23.8％).Multivariate regression analysis revealed that the thoracic abbreviated injury scale (AIS) value(median (IQR) in the AKI group:3 (0-4)],Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) score[median(IQR) in the AKI group:18 (10-27)],CK greater than 5000 U/L,lactic acid concentration at admission,and dobutamine administration were independently associated with AKL Conclusions:We found that age,APACHE Ⅱ score,thoracic trauma,lactic acidosis,and dobutamine administration were independently associated with AKL Trauma surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.