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目的探讨O型血孕妇(其丈夫为非O型血)的抗Ig GA(B)效价与新生儿溶血病(HDN)的关系。方法采用微柱凝胶技术对血型不合的O型血孕妇检测其血清Ig G抗A(B)的效价来观察新生儿溶血病的发病情况。结果与结论在430例O型血孕妇(其丈夫为非O型血)中O—A不合179人占42%,O—B不合184人占43%,O—AB不合67人占15%。其中有41名新生儿出现了新生儿高胆红素血症,随后对其进行了溶血3项的筛查,其中符合ABOHDN诊断的有26例占430名血型不合孕妇所生新生儿的6%。随着孕妇抗Ig GA(B)效价的曾高HDN的发病率明显上升。
Objective To investigate the relationship between anti-Ig GA (B) titer and neonatal hemolytic disease (HDN) in type-O pregnant women (whose husband is non-O type). Methods The microcolumn gel technique was used to detect the serum IgA anti-A (B) titer of non-O-positive pregnant women with different blood types to observe the incidence of hemolytic disease in newborns. RESULTS AND CONCLUSION: Among the 430 O-pregnant women whose husbands were non-O blood type, 179 were O-A patients, 42% were O-B patients, 43% were O-B patients, 184 patients were O-AB patients, and 15% were O-AB patients. Among them, 41 newborns had neonatal hyperbilirubinaemia, followed by three hemolysis screening tests, of which 26% of those diagnosed with ABOHDN accounted for 6% of newborns born of 430 unrelated pregnant women with blood group incompatibility, . As pregnant women with anti-Ig GA (B) titers have a marked increase in the incidence of HDN.