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①目的了解人类乳头瘤病毒（ＨＰＶ）抗原在喉癌组织中的分布情况及其关系。②方法用免疫组织化学方法，对喉癌组织进行了ＨＰＶ抗原检测。③结果６０例病人中，１７例为ＨＰＶ抗原阳性，阳性率为２８％．在１６例高度分化的喉癌中，７例ＨＰＶ抗原阳性（４４％）；在２３例中度分化的喉癌中，８例ＨＰＶ抗原阳性（３５％）；在２１例低度分化的喉癌中，只有２例ＨＰＶ抗原阳性（１０％）。经统计学检验，细胞分化程度高的喉癌组织，其ＨＰＶ抗原检出率明显高于细胞分化程度低者（χ２＝１０．５９，Ｐ＜０．０１）。④结论ＨＰＶ与喉癌的致病有关，且ＨＰＶ抗原检出率与细胞分化程度有关。
Objective To understand the distribution of human papillomavirus (HPV) antigen in laryngeal squamous cell carcinoma and its relationship. ② Methods Immunohistochemistry was used to detect HPV antigen in laryngeal cancer tissues. ③ Results Of 60 patients, 17 were HPV positive, the positive rate was 28%. Seven of the 16 highly differentiated laryngeal cancers were positive for HPV (44%), and of the 23 moderately differentiated laryngeal cancers, 8 were positive for HPV (35%). In 21 patients with poorly differentiated laryngeal cancer Of the 2 cases, only 2 were HPV positive (10%). Statistically, the detection rate of HPV antigen in laryngeal carcinoma with high degree of cell differentiation was significantly higher than that with low degree of cell differentiation (χ2 = 10.59, P <0.01). ④ Conclusion HPV and laryngeal cancer-related, and the detection rate of HPV antigen and cell differentiation.