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目的建立尿液中3-硝基酪氨酸(3-nitrotyrosine,3-NT)在轨检测装置和技术,为评估航天员飞行中应激状态变化提供客观依据。方法基于表面等离子体共振(SPR)原理,研制了在轨医监生化检测装置,并建立了配套的尿液预处理及3-NT检测技术,于“神舟”9号任务中进行了在轨飞行验证。结果在轨检测装置空间工作正常,3-NT检测灵敏度好、准确度高、特异性好,圆满完成飞行中尿液测试。结论建立了尿样中3-NT在轨检测技术,成功应用于空间环境。
OBJECTIVE To establish a 3-nitrotyrosine (3-NT) in-orbit detection device and technique in urine and provide an objective basis for assessing astronaut flight stress changes. Methods Based on the principle of surface plasmon resonance (SPR), a biochemical detection device for on-orbit monitoring was developed and a set of urine pretreatment and 3-NT detection technologies were established. Flight verification. Results The in-orbit detection device was working well in space. The 3-NT detection sensitivity was good, the accuracy was high and the specificity was good. The in-flight urine test was successfully completed. Conclusion The in-orbit detection technology of 3-NT in urine samples was established and successfully applied in space environment.