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目的探讨早期降压治疗对高血压脑出血患者血肿扩大的影响。方法我院急诊收治110例高血压脑出血(HICH)患者,随机分为强化降压组和指南标准降压组,分别给予强化降压及指南标准降压治疗。观察两组治疗后血肿体积的变化和NIHSS评分和死亡率。结果与指南标准降压组血肿扩大率23.3%比较,强化降压组血肿扩大率10.0%明显降低,差异有统计学意义(P<0.05)。发病21d时,强化降压组NIHSS评分明显低于指南标准降压组,差异有统计学意义(P<0.05)。两组死亡率比较差异无统计学意义(P>0.05)。结论早期降压治疗对高血压脑出血患者控制血肿扩大有益。
Objective To investigate the effect of early antihypertensive therapy on hematoma enlargement in patients with hypertensive intracerebral hemorrhage. Methods One hundred and ten hypertensive intracerebral hemorrhage (HICH) patients admitted to our hospital were randomly divided into intensive antihypertensive group and standard antihypertensive group, and were given antihypertensive treatment and standard antihypertensive treatment respectively. The change of hematoma volume and NIHSS score and mortality of the two groups were observed after treatment. Results Compared with the guideline standard hematoma enlargement rate of 23.3%, the enlargement rate of hematoma in intensive antihypertensive group was significantly decreased (10.0%), the difference was statistically significant (P <0.05). On the 21st day of onset, the NIHSS score of intensive antihypertensive group was significantly lower than that of guideline standard antihypertensive group (P <0.05). There was no significant difference in mortality between the two groups (P> 0.05). Conclusion Early antihypertensive treatment of hypertensive intracerebral hemorrhage control hematoma enlargement benefit.