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英国两项随机研究比较了无保护性性交后72h内给与米非司酮(mifepristone)600 mg单剂量口服与Yuzpe口服方法(炔雌醇100μg加左旋18甲基炔诺酮500 μg,12h后重复一次),结果显示,米非司酮组597例中3例妊娠,而Yuzpe法组589例中9例妊娠。然而服用米非司酮易延迟下次月经来潮。米非司酮对卵巢及子宫内膜作用的研究表明,600 mg以下剂量用于紧急避孕有效,而且减少剂量可降低费用,符合药物应使用最低有效剂量的原则。本研究旨在比较无保护性交后120 h(5 d)口服600 mg、50mg与10 mg三种剂量米非司酮的避孕效果与副反应发生率。
Two randomized studies in the UK compared oral single doses of mifepristone 600 mg with Yuzpe 100 μg plus levonorgestrel 18 norethindrone 500 μg within 72 h of unprotected sexual intercourse after 12 h Repeat), the results showed that 3 of 597 women in the mifepristone group were pregnant while 9 of 589 women in the Yuzpe group were pregnant. However, taking mifepristone easily delayed the next menstrual cramps. Studies of the effect of mifepristone on ovarian and endometrial findings have shown that doses below 600 mg are effective for emergency contraception and that reducing doses can reduce costs in line with the principle that the drug should be administered at the lowest effective dose. The purpose of this study was to compare the contraceptive effects and side effects of three doses of mifepristone at doses of 600, 50 and 10 mg administered 120 days (5 days) after unprotected intercourse.