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目的:探讨川芎嗪用于治疗胎儿宫内生长受限(FGR)孕妇脐血流的影响。方法:选择60例FGR孕妇随机分为川芎嗪组30例(A组)和营养支持组30例(B组),另选择同期进行定期产检并分娩的正常孕妇50例作为正常妊娠对照组(C组)。A组行川芎嗪注射液治疗加营养支持,B组给予单纯营养支持治疗,C组嘱左侧卧位不给予其他处理。监测3组孕妇的脐动脉血流、血液流变学参数及新生儿发育情况及体重。结果:经过治疗后,A组的BPD、HC、AC、FL、EFW增长明显,与B组相比差异有统计学意义(P<0.05);A组孕妇脐血流阻力及血液流变学参数明显低于B组,差异有统计学意义(P<0.05);A组的治愈率及总有效率比B组更高,差异有统计学意义(P<0.05)。结论:川芎嗪能明显改善FGR孕妇血液流变性,降低子宫胎盘的循环阻力,改善胎盘绒毛微循环,促进胎儿宫内生长发育,增加新生儿出生体重,总有效率高。
Objective: To investigate the effect of ligustrazine on umbilical blood flow in pregnant women with FGR. Methods: A total of 60 pregnant women with FGR were randomly divided into three groups: group A (30 cases) and group B (30 cases). Another group of 50 normal pregnant women who were regularly checked and delivered during the same period were selected as normal pregnancy control group group). A group of Ligustrazine injection plus nutritional support, B group was treated with simple nutritional support, C group told the left lateral position without giving other treatment. Umbilical artery blood flow, hemorheological parameters and neonatal development and body weight were monitored in 3 groups of pregnant women. Results: After treatment, the BPD, HC, AC, FL and EFW in group A increased significantly compared with that in group B (P <0.05). The blood flow resistance and hemorheological parameters of pregnant women in group A (P <0.05). The cure rate and total effective rate of group A were higher than that of group B, the difference was statistically significant (P <0.05). Conclusion: Ligustrazine can significantly improve the blood rheology of pregnant women with FGR, reduce the circulating resistance of the uterine placenta, improve the microcirculation of the placenta, promote the growth and development of the fetus, and increase the birth weight of the newborn. The total effective rate is high.