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目的探讨骨质疏松症（ＯＰ）患者骨密度（ＢＭＤ）和几种骨代谢参数相互关系及其在ＯＰ发病中的作用与诊断中的意义。方法随机选择绝经后妇女７４例，根据ＢＭＤ分为ＯＰ组、非ＯＰ组，以绝经前妇女３１例为对照组，将３组中ＢＭＤ与白细胞介素－６（ＩＬ－６），雌二醇（Ｅ２），骨钙素（ＢＧＰ），碱性磷酸酶（ＡＬＰ），血清钙（Ｃａ）和磷（Ｐ）等进行比较。结果ＢＭＤ与骨代谢参数的表现为：ＢＭＤ与ＩＬ－６、ＢＧＰ、ＡＬＰ呈负相关（ｒ分别为－０．５５８，－０．５３２，－０．４１９），与Ｅ２呈正相关（ｒ＝０．４０５），与Ｃａ和Ｐ无显著性相关关系（ｒ分别为０．０７３，０．０８０），结果显示：随血清雌激素水平下降ＢＭＤ减少，ＢＭＤ减少时，血清ＩＬ－６、ＢＧＰ、ＡＬＰ水平则升高。结论ＩＬ－６高表达与ＯＰ发病以及雌激素减少有关，血清雌激素水平下降可能导致ＩＬ－６分泌增多，ＩＬ－６水平升高，则可能是引起骨丢失原因之一
Objective To investigate the relationship between bone mineral density (BMD) and several bone metabolism parameters in patients with osteoporosis (OP) and its significance in the pathogenesis and diagnosis of OP. Methods A total of 74 postmenopausal women were randomly divided into OP group and non-OP group according to BMD. Thirty-one premenopausal women were used as control group. BMD, interleukin-6 (IL-6), estradiol (E2), BGP, ALP, Ca, P and so on. Results BMD and bone metabolism parameters were as follows: BMD was negatively correlated with IL-6, BGP and ALP (r = -0.558, -0.532, -0.419, respectively) .405), but no significant correlation with Ca and P (r = 0.073,0.080, respectively). The results showed that with the decrease of serum estrogen, the decrease of BMD, The level is higher. Conclusion The high expression of IL-6 is associated with the onset of OP and the decrease of estrogen. The decrease of serum estrogen level may lead to the increase of IL-6 secretion and the increase of IL-6, which may be one of the causes of bone loss