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目的:研究CYP4A11基因单核苷酸多态性与高血压的相关性。方法:收集304例日本高血压患者(高血压组)和207例年龄匹配、血压正常的日本人(对照组),选择CYP4A11基因的3个单核苷酸多态性(SNPs,rs2269231,rs9333025,rs1126742),应用TaqMan SNP基因分型的方法进行基因分型,分析并比较不同性别高血压组和对照组3个SNPs基因型频率和等位基因频率的分布,并应用Logistic回归分析方法分析高血压主要危险因素对结果的影响,分析CYP4A11基因与高血压的相关性。结果:全体,高血压组和对照组rs1126742的基因型分布差异有统计学意义(P=0.005);对于全体、男性、女性,高血压组和对照组的rs1126742的隐性模型分布(CCversus CT+TT)存在差异(P分别为0.007、0.043、0.045);Logistic回归分析显示,对于全体和男性,rs1126742的CT+TT基因型更常见于高血压患者(P分别为0.015、0.048)。结论:CYP4A11基因的rs1126742可作为日本男性高血压标志,其CT+TT基因型与日本男性高血压有关。
Objective: To investigate the association between CYP4A11 single nucleotide polymorphisms and hypertension. Methods: A total of 304 Japanese hypertensive patients (hypertension group) and 207 age-matched and normotensive Japanese subjects (control group) were enrolled in this study. Three SNPs of CYP4A11 gene (SNPs, rs2269231, rs9333025, rs1126742). Genotypes were genotyped by TaqMan SNP genotyping. The frequencies of genotypes and alleles of three SNPs in different genders and controls were analyzed and compared. Logistic regression analysis was used to analyze the prevalence of hypertension The main risk factors on the results, analysis of CYP4A11 gene and hypertension correlation. Results: The genotype distribution of rs1126742 in the whole, hypertensive and control groups was statistically significant (P = 0.005). The recessive model distribution of rs1126742 in all, male, female, hypertensive and control groups (CCversus CT + TT) (P = 0.007, 0.043,0.045, respectively). Logistic regression analysis showed that the CT + TT genotype of rs1126742 was more common in hypertensive patients (P = 0.015 and 0.048, respectively) for all and men. Conclusion: rs1126742 of CYP4A11 gene can be used as a marker of hypertension in Japanese men and the CT + TT genotype is associated with Japanese male hypertension.