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介绍了用磺酸水杨酸作催化剂,在无溶剂条件下,利用Biginelli反应,一锅合成3,4-二氢嘧啶-2(1H)-酮的方法。这种方法和传统的Biginelli反应条件比较,有反应时间短(4~7h)和收率高(71%~96%)的特点。
The method of synthesizing 3,4-dihydropyrimidin-2 (1H) -one in one pot by using Biginelli reaction in the absence of solvent was introduced with sulfosalicylic acid as catalyst. Compared with the traditional Biginelli reaction conditions, this method has the characteristics of short reaction time (4 ~ 7h) and high yield (71% ~ 96%).