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目的 :研究黄芪甲苷在家兔体内的药动学和在大鼠的排泄。方法 :健康家兔和大鼠一次静脉注射 (静注 )给予黄芪甲苷 4mg·kg- 1,高效液相色谱 蒸发光散射检测器法检测兔血浆和大鼠尿及粪黄芪甲苷浓度 ,用 3P97药动学软件对兔血浆浓度 时间数据进行动力学分析和计算药动学参数 ,并估算大鼠体内的排泄情况。结果 :黄芪甲苷静注给药后 ,T12 α 为 0 .10h ,T12 β 为 1.4h ,Vc 为 0 .15L·kg- 1,VD 为 0 .6L·kg- 1,Cl为 0 .32L·h- 1·kg- 1,AUC为 15mg·L- 1·h。大鼠静注给药后 ,原形从尿和粪排出量分别为给药量的 16 %和 3.2 %。结论 :家兔体内黄芪甲苷的动力学过程符合二室模型 ,大鼠仅有少量原形药物从尿和粪排泄。
Objective: To study the pharmacokinetics of astragaloside IV in rabbits and its excretion in rats. METHODS: Astragaloside 4 mg·kg-1 was administered by intravenous injection (intravenous injection) to healthy rabbits and rats. The concentration of rabbit plasma and rat urine and decoction Astragaloside IV was determined by HPLC with evaporative light scattering detector. 3P97 pharmacokinetic software performed kinetic analysis of rabbit plasma concentration time data and calculated pharmacokinetic parameters, and estimated excretion in rats. Results: After administration of astragaloside IV, T12 α was 0.1 h, T12 β was 1.4 h, Vc was 0.15 L·kg-1, VD was 0.6 L·kg-1, Cl was 0.32 L· H- 1·kg-1, AUC was 15 mg·L- 1·h. After intravenous administration in rats, the original urine and fecal output were 16% and 3.2% of the dose, respectively. Conclusion : The kinetics of astragaloside IV in rabbits was in accordance with the two-compartment model. Rats had only a small amount of original drugs excreted in urine and feces.