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用三氯化铁局部涂抹损伤血管形成的大鼠大脑中动脉血栓模型 (MCAT) ,观察通解定风片预防给药、治疗给药对行为障碍、脑梗塞范围、脑水肿程度的影响。结果表明通解定风片 6、3、1.5g/ kg组预防给药七天 ,可使脑梗塞范围分别减少 6 2 %、6 3%、2 0 % ,并使脑含水量下降 ,改善行为障碍程度 ;治疗给药五次 ,通解定风片 6 g/ kg组 ,亦对脑缺血各项指标具有改善作用。由此可见通解定风片对大鼠大脑中动脉血栓所致局部脑缺血具有一定的预防和治疗作用
The middle cerebral artery thrombosis model (MCAT) in rats with damaged blood vessels was locally applied with ferric chloride to observe the effect of Tongfu Dingfeng Tablets on the prevention of drug administration, on the behavioral disorders, the extent of cerebral infarction, and the degree of cerebral edema. The results showed that the Tongjie Fengfeng tablets 6, 3, 1.5 g / kg group preventive administration for seven days, can reduce the scope of cerebral infarction by 62%, 63%, 20%, and reduce the brain water content, improve the degree of behavioral disorders Five times of treatment administration and solution of 6 g/kg of wind-fixing tablets also improved the cerebral ischemia. This shows that Tong Jie Ding Feng Pian has a preventive and therapeutic effect on focal cerebral ischemia induced by middle cerebral artery thrombosis in rats.