目的:雷公藤具有清热解毒、祛风除湿、消肿止痛、杀虫止痒的功用,现代药理研究亦表明其具有抗炎、镇痛、抗肿瘤及免疫调节等作用,临床主要用于治疗免疫性疾病、肾脏性疾病、皮肤性疾病等,对治疗类风湿性关节炎疗效尤为显著。但因其具有严重的毒副反应,尤其是肝肾毒性,限制了雷公藤的临床安全应用,成为了迫切需要解决的难题。虽然目前存在的减毒方式众多,包括传统的净制减毒、炮制减毒、配伍减毒和现代的制剂减毒、结构修饰减毒、生物技术减毒以及其相互间的联合应用等,但并没有本质上解决雷公藤的安全问题。在古代医药文献中药物的毒性常指这种药物的偏性,在中医药理论看来,作为药物都有毒性,关键是正确使用。中药的配伍使用是中医药文化的重要组成部分,从春秋战国时期的配伍雏形,到《黄帝内经》中的已有君臣佐使配伍用药的方剂,再到《神农本草经》中的配伍理论的形成,到最后《伤寒论》经典名方的传世,记录了中药配伍应用的发展,也记录了中药配伍使用的重要意义,随着中药事业逐渐走向现代化和国际化,中药配伍又有了进ー步的发展,开始迈向质量可控、机制清楚的组分配伍,故本文以雷公藤配伍减毒为中心,以配伍形式的发展为主线,对雷公藤配伍减毒进行综述,为雷公藤减毒增效研究提供思路,促进其合理开发和临床安全应用,也为其他有毒中药的合理应用提供参考。 Objective: Tripterygium with detoxification, expelling wind and dehumidification, swelling painkillers, insecticidal itching function, modern pharmacological studies have also shown that it has anti-inflammatory, analgesic, anti-tumor and immune regulatory role, the main clinical treatment for immune Sexually transmitted diseases, kidney diseases, dermatological diseases, etc. are particularly effective in treating rheumatoid arthritis. However, due to its serious side effects, especially liver and kidney toxicity, limiting the clinical safety of Tripterygium wilfordii has become an urgent problem to be solved. Although there are many ways of attenuating drugs currently available, including the traditional method of reducing toxin, concocting to reduce toxicity, reducing the weight of drugs and reducing the dosage of modern preparations, attenuating the structure modification, reducing the toxicity of biotechnology and their mutual application, etc. It does not essentially solve the problem of triptolide safety. Drugs in the ancient medical literature often refers to the toxicity of this drug in the theory of traditional Chinese medicine, as drugs are toxic, the key is the proper use. The compatibility of traditional Chinese medicine is an important part of traditional Chinese medicine culture. From the prototype of compatibility during the Spring and Autumn Period and the Warring States period to the prescription of the compatibility between the monarch and minister in the Huangdi Nei Jing and the compatibility theory in Shen Nong Ben Cao Jing, To the last “Treatise on Febrile Diseases,” the classic name of the world handed down, recorded the compatibility of traditional Chinese medicine application development, but also recorded the importance of the compatibility of traditional Chinese medicine, with the gradual modernization of Chinese medicine and internationalization, Chinese medicine has another step into the compatibility Development and start to control the quality and mechanism of a clear component of the compatibility, so this article with triadimetic compatibility as the center, with the development of compatibility as the main line, the triptolide compatibility attenuated were summarized as Tripterygium attenuated by Effective research to provide ideas to promote their rational development and clinical safety applications, but also for the rational use of other toxic herbs provide a reference.