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目的观察A型肉毒素素(BTXA)对偏侧面肌痉挛(HFS)患者痉挛程度的改善和焦虑状况的影响。方法对40例HFS患者进行局部注射BTXA,治疗前和治疗后1个月分别对患者的痉挛程度进行评定,同时采用Zung氏焦虑自评量表(SAS)评价焦虑状况。结果57.5%的HFS患者在BTXA治疗后1个月痉挛完全缓解,32.5%的HFS患者在BTXA治疗后1个月痉挛明显缓解,而且治疗后患者焦虑状况的评分均低于治疗前,差异有统计学意义(P<0.001)。结论局部注射BTXA可迅速缓解或消除HFS患者肌肉痉挛,改善患者的心理状况。
Objective To investigate the effect of BTXA on the degree of spasticity and anxiety in patients with hemifacial spasm (HFS). Methods Forty patients with HFS were injected with BTXA locally. The severity of spasticity was assessed before treatment and one month after treatment. Anxiety was assessed by Zung’s self-rating anxiety scale (SAS). Results 57.5% of HFS patients had complete remission of spasm 1 month after BTXA treatment, 32.5% of HFS patients had a significant relieve of spasm 1 month after BTXA treatment, and the scores of anxiety after treatment were lower than those before treatment Significance (P <0.001). Conclusion Local injection of BTXA can quickly relieve or eliminate muscle spasms in HFS patients and improve their psychological status.