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目的观察尼可地尔与硝酸甘油用于治疗不稳定型心绞痛的临床效果,探讨其临床意义。方法回顾性分析我科2010年1月-2011年1月收治的94例不稳定型心绞痛患者的临床资料,观察尼可地尔治疗与硝酸甘油治疗的临床效果,并进行对比分析。结果尼可地尔组患者在用药后48h后心电图改善有效率为明显高于硝酸甘油组,尼可地尔组在治疗1h、6h心肌耗氧量均高于硝酸甘油组,组间比较均有统计学意义(P<0.05);两组患者不良反应总发生率比较无显著差异(P>0.05)。结论尼可地尔治疗不稳定型心绞痛临床疗效优于硝酸甘油治疗,是目前治疗不稳定性心绞痛的一种较佳药物,值得临床推广应用。
Objective To observe the clinical effect of nicorandil and nitroglycerin in the treatment of unstable angina pectoris and to explore its clinical significance. Methods The clinical data of 94 patients with unstable angina pectoris admitted in our department from January 2010 to January 2011 were retrospectively analyzed. The clinical effects of nicorandil and nitroglycerin were observed and compared. Results In 48 hours after treatment, the patients in nicorandil group had better ECG improvement efficiency than those in nitroglycerin group and nicardipril group at 1 hour and 6 hours after treatment, the myocardial oxygen consumption was higher than that of nitroglycerin group (P <0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P> 0.05). Conclusion Nicorandil is superior to nitroglycerin in the treatment of unstable angina pectoris. It is a better drug for the treatment of unstable angina pectoris and is worthy of clinical application.