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目的了解北京市2005年接种吸附百白破联合疫苗(DPT)后无菌化脓病例增多的原因,保证安全接种。方法对北京市2005年接种DPT后107例无菌化脓进行描述流行病学分析。结果北京市2005年共报告107例无菌化脓,发生率为19.58/10万人次。83%(15/18)的区(县)报告了无菌化脓,共涉及6个批号DPT,其中80%的病例涉及2个批号,发生率分别为27/10万人份、15/10万人份。结论北京市2005年接种DPT后无菌化脓病例增多主要原因可能为:①DPT更换生产厂家,部分批号DPT的质量可能存在问题;②预防接种不良反应监测系统敏感性提高。疫苗生产厂家应改善工艺、提高质量,建议使用无细胞百白破联合疫苗。
Objective To understand the reasons for the increase of aseptic purulent cases after inoculation of diphtheria combination vaccine (DPT) in Beijing in 2005 to ensure safe vaccination. Methods The epidemiological analysis of 107 cases of sterile pus after DPT inoculation in Beijing in 2005 was described. Results In 2005, 107 cases of sterile suppuration were reported in Beijing. The incidence rate was 19.58 / 100000. 83% (15/18) of districts (counties) reported aseptic pus involving a total of 6 DPT batches, 80% of which involved 2 batches, with a rate of 27/10 million and 15/10 million respectively People. Conclusions The main reasons for the increase of aseptic purulent cases after inoculation of DPT in Beijing in 2005 are as follows: (1) There may be some problems in the quality of DPT replaced by DPT manufacturers; (2) the sensitivity of vaccination adverse reaction monitoring system is improved. Vaccine manufacturers should improve the process, improve quality, it is recommended to use cell-free diphtheria combined vaccine.