论文部分内容阅读
发热是一种前见的病理过程,是不少疾病发生,发展的重要讯号。近30多年来一系例研究证明:内源性致热原(EndogenousPyrogen,以下简称EP)几乎是一切发热反应的共同介质;发热不是机体神经系统调节障碍的结果,而是人类和高等动物机体在长期进化过程中所形成的对致热物质刺激的一种主动的防御适应性反应。由于大多数外源性致热原(如内毒素)的分子量大(通常达1～2百万)、结构复杂(内毒素是磷脂-多糖-蛋白质的复合物),不大可能通过血脑屏障而直接作用于丘脑下部体温调节中枢的神经元。因此长期以
Fever is a pre-pathological process, is an important signal for the occurrence and development of many diseases. In the past 30 years, a series of studies have shown that endogenous pyrogen (EndogenousPyrogen, hereinafter referred to as EP) is almost the common medium of all fever reactions; fever is not the result of the body’s nervous system disorders, but the human and higher animal body in An active defense-adaptive response to the thermogenic stimuli created during long-term evolution. Since most exogenous pyrogen (such as endotoxins) have a large molecular weight (usually 1-2 million) and a complex structure (endotoxin is a phospholipid-polysaccharide-protein complex), it is unlikely that the exogenous pyrogen causes a blood-brain barrier While directly acting on the hypothalamus neurons in the thermoregulatory center. So long