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Ph染色体是慢性粒细胞性白血病(CML)的标记,约90%CML病人可检出Ph染色体(Ph+),10%左右的病例Ph阴性(Ph-),在Ph-/ber+病人,其临床过程通常与典型Ph+CML相似。关于Ph-/ber-CML目前报道尚少,作者在过去5年间对211例CML的诊治过程中,发现13例(6%)Ph-/ber-CML病例,本文介绍这些病人的生物学及临床特点。男性8例,女性5例,年龄38～77岁(平均62)仅1例年龄<55岁,所有病人均有脾肿大,平均WBC计数50×10~9/L,血小板130×10~9/L,6例血红蛋白≤10g/L。外周
The Ph chromosome is a marker of chronic myeloid leukemia (CML). About 90% of CML patients can detect Ph chromosomes (Ph +), about 10% of Ph negative cases (Ph-), and in Ph- / ber + patients, their clinical course It is usually similar to a typical Ph + CML. About Ph- / ber-CML There are few reports on the incidence of Ph- / ber-CML. The authors found 13 cases (6%) of Ph- / C-CML cases during the treatment of 211 CML in the past 5 years. Features. There were 8 males and 5 females, with a mean age of 62 years (range: 62 to 62 years old). Only 1 patient was 55 years old. All patients had splenomegaly with a mean WBC count of 50 × 10 ~ 9 / L and platelets of 130 × 10 ~ 9 / L, 6 cases of hemoglobin ≤ 10g / L. Peripheral