骨桥蛋白是一种多功能细胞外基质蛋白,广泛分布于多种组织,参与多种病理过程。过去认为骨桥蛋白主要参与骨形成,近期发现其作为细胞因子介导细胞的趋化作用、聚集、黏附、增殖和迁移。骨桥蛋白在肺部疾病中广泛表达,调节肺结核肉芽肿的生成、参与特发性肺纤维化的发病及恶性肿瘤的转移,对肺部多种疾病有诊断及潜在治疗意义。 Osteopontin is a multifunctional extracellular matrix protein widely distributed in many tissues and involved in many pathological processes. In the past that osteopontin is mainly involved in bone formation, recently found as a cytokine-mediated chemotaxis, aggregation, adhesion, proliferation and migration. Osteopontin is widely expressed in lung diseases and regulates the formation of tuberculosis granuloma. It is involved in the pathogenesis of idiopathic pulmonary fibrosis and metastasis of malignant tumors. It has the potential to diagnose and treat various diseases in the lung.