目的探讨肝细胞癌变过程中超微结构变化特点。方法对二乙基亚硝胺诱癌中大鼠肝脏不同病变阶段的超微结构进行动态观察。结果在诱癌的早、中、晚期发展过程中，损伤肝细胞的核、核仁、胞浆内糖原以及胞浆内细胞器，如线粒体、粗面内质网和滑面内质网等的变化有一定规律。结论随诱癌时间延长，肝细胞逐渐出现变性、异型乃至癌细胞的阶段性超微结构特征 Objective To investigate the characteristics of ultrastructural changes during hepatocellular carcinogenesis. Methods The ultrastructural changes of rat liver during different phases of lesions were observed dynamically with diethylnitrosamine. Results In the early, middle and late stages of carcinogenesis, the nuclear, nucleoli, intracytoplasmic glycogen, and cytoplasmic organelles of hepatocytes such as mitochondria, rough endoplasmic reticulum, and smooth endoplasmic reticulum were damaged. There are certain rules for change. Conclusion With the prolongation of cancer induction time, progressive ultrastructural features of liver cells gradually degenerate, heterogeneous and even cancerous cells.