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晚近的研究表明,在充血性心力衰竭(CHF)病人中,血管紧张素转换酶抑制剂是有效的血管扩张剂.其典型的血流动力学效应表现为左心室充盈压下降,心排出量(CO)增加和平均动脉压(MAP)下降.虽可预料转换酶抑制剂的血流动力学即时效应有赖于基础肾素-血管紧张素活性的高低,但尚未证实.转换酶抑制剂远期疗效与血浆肾素活性(PRA)之间的关系也未仔细估价.本文旨在探讨充血性心力衰竭病人中转换酶抑制剂即时和远期临床及血流动力学效应的决定因素,特别是血浆肾素活性对转换酶抑制剂血流动力学有益效应的预测价值.
Recent studies have shown that angiotensin-converting enzyme inhibitors are potent vasodilators in patients with congestive heart failure (CHF), and their typical hemodynamic effects are decreased left ventricular filling pressure, cardiac output CO) and mean arterial pressure (MAP) decline.Although it is anticipated that the immediate hemodynamic effects of ACE inhibitors depend on the basal renin-angiotensin activity level, the long-term efficacy of the ACE inhibitors has not been demonstrated And plasma renin activity (PRA) have not been carefully evaluated.This paper aims to investigate the immediate and long-term clinical and hemodynamic effects of converting enzyme inhibitors in patients with congestive heart failure, in particular, plasma renin Predictive value of prime activity on the hemodynamic benefit of converting enzyme inhibitors.