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目的分析研究胺碘酮防止急性心肌梗死(AMI)再灌注恶性心律失常(RA)的作用。方法随机分成对照组和治疗组,每组各48例,对照组给予尿激酶常规溶栓治疗,治疗组溶栓前加用胺碘酮维持静脉滴注至少4h,监测RA的发生率。结果对照组RA、室颤及病死率分别为84.21%、18.42%、10.52%。而治疗组分别为48.645%、10.08%、2.7%。两组相比,差异有统计学意义(“P<0.05”)。结论胺碘酮能预防和减少AMI的RA、室颤发生率,提高室颤抢救成功率。
Objective To investigate the role of amiodarone in preventing reperfusion of malignant arrhythmias (AMI) after acute myocardial infarction (AMI). Methods Randomly divided into control group and treatment group, 48 cases in each group. The control group was given routine thrombolytic therapy of urokinase. Amiodarone in the treatment group was intravenously dripped for at least 4 hours to monitor the incidence of RA. Results RA, ventricular fibrillation and mortality in the control group were 84.21%, 18.42% and 10.52% respectively. The treatment group were 48.645%, 10.08%, 2.7%. The differences between the two groups were statistically significant ( “P <0.05 ”). Conclusions Amiodarone can prevent and reduce the incidence of RA and VF and improve the success rate of VF rescue.