自从 Hughes 等第一次从猪脑分离到内源性吗啡样物质以来,人们对它的生理作用进行了广泛研究。结果表明,它不仅参与神经系统中内在抗痛机制,而且具有更为广泛的生理及病理生理意义。其中,关于脑内吗啡物质参与心血管活动的调节作用,近几年来国内外也积累了一些实验资料。本文将综合一些学者的意见作一初步讨论。 Since Hughes et al. First isolated endogenous morphine-like substances from the porcine brain, extensive research has been conducted on its physiological role. The results showed that it not only involved in the nervous system intrinsic mechanism of pain, but also has a broader range of physiological and pathophysiological significance. Among them, morphine substances in the brain involved in cardiovascular regulation, in recent years at home and abroad have also accumulated some experimental data. This article will synthesize the opinions of some scholars for a preliminary discussion.