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水浴加热条件下制得放射化学纯度大于90%的188Re-tetrofosmin配合物。188Re-tetrofosmin在制备后室温放置6h,放化纯度无明显变化,小鼠生物分布实验显示该配合物与具有亲肿瘤性的心肌显像剂188Tc-tetrofosmin有相似的生物性质,188Re-tetrofosmin应为具有反式双氧中心核结构的+1价配合物。
The 188Re-tetrofosmin complex with radiochemical purity greater than 90% was prepared under water bath heating conditions. 188Re-tetrofosmin after the preparation for 6h at room temperature, no significant change in radiochemical purity, the mice biodistribution experiments showed that the tumor with a tumor imaging agent 188Tc-tetrofosmin have similar biological properties, 188Re-tetrofosmin should be +1 complex with a trans-bidentate central core structure.