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P物质 (SP)属于速激肽家族 ,是最早发现的一种神经肽 ,其在痛觉调制、心血管活动和胃肠道运动中发挥重要作用。有文献报道肌肉或腹腔注射SP可使小鼠产生镇静作用 ;在体或离体实验均发现SP可使一些促眠因子产生增加[1] 。据此 ,我们推测SP可能参与机体睡眠 -觉醒周期调节 ,然而
Substance P (SP), a member of the tachykinin family, is the earliest discovered neuropeptide that plays an important role in pain modulation, cardiovascular activity and gastrointestinal motility. It has been reported in the literature that intramuscular or intraperitoneal injection of SP can sedative effect in mice; in vivo or in vitro experiments found that SP can make some increase in the production of sleep factors [1]. Accordingly, we speculate that SP may be involved in the body’s sleep-wake cycle regulation, however