Four types of chiral thiazolidine derivatives were synthesized conveniently from natural L-cysteine and showed good enantioselectivity in up to 90% ee in the addition of diethylzinc to benzaldehyde. Their enantioselectivity was affected by the bulkiness of R and the thiazolidine ring systems in their molecules. Four types of chiral thiazolidine derivatives were derived conveniently from natural L-cysteine ​​and showed good enantioselectivity in up to 90% ee in the addition of diethylzinc to benzaldehyde. Their enantioselectivity was affected by the bulkiness of R and the thiazolidine ring systems in their molecules.