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通过喂饲高胆固醇饲料复制家兔主动脉粥样硬化（ＡＳ）模型，呈现ＡＳ早期和晚期的变化。在ＡＳ进程中显示：（１）血清总胆固醇浓度呈明显升高趋势（Ｐ＜０．０１），（２）红细胞膜钠泵活性逐渐降低（Ｐ＜０．０１）；（３）红细胞膜收缩蛋白（ＳＰ）相对含量下降（Ｐ＜０．０５～０．０１）．胆固醇浓度与钠泵活性、ＳＰ含量间分别呈显著或非常显著负相关（ｒ＝－０．５１０７～－０．６７２１，Ｐ＜０．０５～０．０１；ｒ＝－０．７３０９～－０．７９４４，Ｐ＜０．０１）；钠泵活性与ＳＰ含量间呈显著或非常显著正相关（ｒ＝０．４７５０～０．５２９１，Ｐ＜０．０５～０．０１）。提示胆固醇浓度的升高与钠泵活性降低间有密切关联，而胆固醇浓度和钠泵活性的上述变化也与ＳＰ含量降低有一定关系。本文提出，在ＡＳ进程中除胆固醇的影响外，钠泵活性和ＳＰ含量的改变通过降低红细胞变形性这一途径也对ＡＳ形成有一定促进作用。：Ｐ＜０．０１．ｃｏｍｐａｒｅｄｗｉｔｈＡＧ１．２ＳＰ相对含量的变化（Ｔａｂ２）结果显示ＣＧ１、ＣＧ２ＳＰ含量相对恒定（Ｐ＞０．０５）；而ＡＧ１、ＡＧ２ＳＰ明显下降（Ｐ＜０．０５～０．０１）。Ｔａｂ２Ｃｈａｎｇｅｓｉｎｓｐｅｃｔｒｉｎｃｏｎｔｅｎｔ?
Rabbit aortic atherosclerosis (AS) model was replicated by feeding high cholesterol feed, showing early and late changes of AS. (1) Serum total cholesterol concentration increased significantly (P <0.01), (2) erythrocyte membrane sodium pump activity gradually decreased (P <0.01), (3) erythrocyte membrane contraction The relative content of protein (SP) decreased (P <0.05 ~ 0.01). There was a significant or very significant negative correlation between cholesterol concentration and sodium pump activity and SP content (r = -0.5107 ~ -0.6721, P <0.05 ~ 0.01; r = -0.7309 ~ -0 .7944, P <0.01). There was a significant or very significant positive correlation between sodium pump activity and SP content (r = 0.4750-0.5291, P <0.05-0.01). It is suggested that there is a close relationship between the increase of cholesterol concentration and the decrease of sodium pump activity. The above changes of cholesterol concentration and sodium pump activity are also related to the decrease of SP content. This paper suggests that in addition to the effect of cholesterol in the AS process, changes in sodium pump activity and SP content may also contribute to AS formation by reducing the erythrocyte deformability. : P <0.01. ComparedwithAG1.2SP relative content change (Tab2) results showed CG1, CG2SPcontent is relatively constant (P> 0.05), and AG1, AG2SP decreased significantly (P <0.05 ~ 0.01). Tab2Changesinspectrincontent?