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目的分析血清脂蛋白(a)[Lp(a)]和胱抑素C(Cys-C)在2型糖尿病(T2DM)以及微血管并发症患者中的变化,探讨其与T2DM及微血管并发症之间的关系。方法分别测定各组糖化血红蛋白(Hb A1c)、低密度脂蛋白(LDL)、尿素氮(BUN)、血肌酐(SCr)、Lp(a)和Cys-C水平,比较其与微血管并发症的关系。结果 T2DM患者的血清Lp(a)和Cys-C水平升高,差异有统计学意义(P<0.05)。与无微血管病变的T2DM组相比,DR组和DPN组血清Lp(a)水平升高,而DN组血清Lp(a)和Cys-C水平均升高,并且随着尿白蛋白排泄率(UAER)的升高,血清Lp(a)、Cys-C水平逐渐升高,差异均有统计学意义(P<0.05)。Logistic回归分析显示,高水平的Lp(a)是2型糖尿病患者发生糖尿病肾病的危险因素。结论血清Lp(a)和Cys-C与2型糖尿病及微血管并发症具有相关性,Lp(a)在糖尿病肾病的早期就发生改变,同时检测血清Lp(a)和Cys-C对糖尿病微血管病变的早期发现有重要意义。
Objective To analyze the changes of serum lipoprotein (a) [Lp (a)] and cystatin C (Cys-C) in type 2 diabetes mellitus (T2DM) and microvascular complications in patients with T2DM and microvascular complications Relationship. Methods The levels of Hb A1c, LDL, BUN, SCr, Lp (a) and Cys-C in each group were measured and compared with those of microvascular complications . Results Serum Lp (a) and Cys-C levels in T2DM patients were significantly higher than those in T2DM patients (P <0.05). Serum Lp (a) level was increased in DR group and DPN group compared with T2DM group without microangiopathy, and serum Lp (a) and Cys-C levels were increased in DN group. With the increase of urinary albumin excretion rate UAER), serum Lp (a), Cys-C levels gradually increased, the differences were statistically significant (P <0.05). Logistic regression analysis showed that high level of Lp (a) was a risk factor for diabetic nephropathy in type 2 diabetic patients. Conclusions Serum Lp (a) and Cys-C are associated with type 2 diabetes mellitus and microvascular complications. Lp (a) changes in the early stage of diabetic nephropathy. Simultaneous detection of serum Lp (a) and Cys-C on diabetic microangiopathy Early detection of great significance.