目的　探讨胆囊结石与大肠癌之间的关系。方法　应用大样本、回顾性病例对照方法 ,对上海市闵行区七大工矿企业职工中胆囊结石病例数、大肠癌病例数、胆囊结石患大肠癌的病例数、性别、年龄、肿瘤发生部位等进行调查和统计学分析 ;对胃癌作同样分析。结果　 (1)胆囊结石(胆囊未切除 )患大肠癌与无胆囊结石患大肠癌比较 :RR =3 6 5 (95 %CI,1 73～ 6 31) ,P =0 0 0 0 3;(2 )胆囊结石患胃癌与无胆囊结石患胃癌比较 :RR =0 6 0 (95 %CI,0 16～ 2 41) ,P =0 4744。结论　胆囊结石增加大肠癌发病的危险性 ,是大肠癌发生的高危因素。胆囊结石患胃癌与无胆囊结石患胃癌相比 ,二者无显著差异。 Objective To investigate the relationship between gallstone and colorectal cancer. Methods A large sample and a retrospective case-control study were performed on the cases of gallbladder stones, the number of colorectal cancer patients, the number of colorectal cancer patients with gallstones, sex, age and tumor site in the seven industrial and mining enterprises in Minhang District, Shanghai Investigation and statistical analysis; The same analysis of gastric cancer. Results (1) The incidence of colorectal cancer in patients with or without gallbladder stones was significantly higher than that in patients without gallbladder stones (RR = 356% (95% CI, 73-63), P = 0.00003; ) Gallstone with gastric cancer and no gallstone patients with gastric cancer: RR = 0 60 (95% CI, 0 16 ~ 2 41), P = 0 4744. Conclusion Gallstone increases the risk of colorectal cancer and is a risk factor for colorectal cancer. Gallbladder stones suffering from gastric cancer and gallbladder stones compared to gastric cancer, there was no significant difference between the two.