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长时程增强是神经系统信息储存的细胞水平模型,被认为是学习和记忆的形成机制。长时程增强电生理技术常用于促进记忆药物的筛选实验。海马齿状回长时程增强筛选研究发现,异地衣糖能在20 pulses/100Hz的刺激条件下诱导出长时程增强,而单独应用该刺激条件并不能诱导出长时程增强。研究经验表明具有这样作用的受试药物,往往能够拮抗30%乙醇抑制30 pulses/60Hz刺激条件诱导的长时程增强,比如藏红花醇提物。但在随后的研究中发现,异地衣糖不能拮抗30%乙醇对30 pulses/60Hz刺激条件诱导的长时程增强,提示异地衣糖与藏红花醇提物的促进长时程增强作用机制不同,是通过某一未知的新机制实现的。
Long-term potentiation is a cellular-level model of information storage in the nervous system and is thought to be the mechanism of learning and memory formation. Long-term potentiation electrophysiological techniques are commonly used to facilitate screening experiments for memory drugs. A long-term potentiation screening study of the dentate gyrus in the hippocampus found that irreversible lichen induces long-term potentiation at 20 pulses/100 Hz stimulation. However, long-term potentiation could not be induced by this stimulation alone. Research experience has shown that drugs with this effect often antagonize 30% ethanol inhibition of long-term potentiation induced by 30 pulses/60 Hz stimulation conditions, such as saffron alcohol extracts. However, in the subsequent study, it was found that iso- lichenin could not antagonize the long-term potentiation induced by 30% ethanol at 30 pulses/60Hz stimulation, suggesting that the mechanism of long-term potentiation of iso- lichenigar and the alcohol extract of saffron was different. Through an unknown new mechanism.