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目的探讨应用纳洛酮治疗急性亚硝酸盐中毒的临床效果。方法 39例急性亚硝酸盐中毒患者,根据入院前后顺序分为观察组(18例)和对照组(21例)。对两组患者均进行常规治疗。对照组在常规治疗基础上给药亚甲蓝,观察组在对照组基础上加药纳洛酮。比较两组患者平均救治时间、救治后生命体征和意识恢复的时间及不良反应发生率和死亡率。结果观察组的平均救治时间、救治后生命体征和意识恢复的时间显著短于对照组(P<0.05);观察组死亡率显著低于对照组(P<0.05),但两组不良反应发生率比较差异无统计学意义(P>0.05)。结论对于急性亚硝酸盐中毒患者,可以在常规抢救的基础上给药亚甲蓝和纳洛酮,以加快体征恢复速度,降低死亡率。
Objective To investigate the clinical effect of naloxone in the treatment of acute nitrite poisoning. Methods Thirty-nine patients with acute nitrite poisoning were divided into observation group (n = 18) and control group (n = 21) according to the order of admission. Both groups were treated routinely. The control group was given methylene blue on the basis of routine treatment. The observation group was given naloxone on the basis of the control group. The average treatment time, the vital signs and recovery of consciousness, the incidence of adverse reactions and the mortality rate were compared between the two groups. Results The average treatment time, the vital signs after treatment and the recovery time of consciousness in observation group were significantly shorter than those in control group (P <0.05). The mortality in observation group was significantly lower than that in control group (P <0.05), but the incidence of adverse reactions The difference was not statistically significant (P> 0.05). Conclusion For patients with acute nitrite poisoning, methylene blue and naloxone can be administered on a routine basis to speed up the recovery of signs and reduce the mortality rate.