食欲肽是下丘脑神经元分泌的一种神经递质或神经调质 ,主要作用是促进摄食 ,增加体重。食欲肽诱发摄食过量的机制与下丘脑其它食欲调节神经肽的作用有关。本文综述了食欲肽及其受体的分布 ;与瘦素、神经肽Y、促肾上腺皮质激素释放因子、可卡因和安非他明调节的转录因子、5 羟色胺等相互作用的研究进展 Orexin is a neurotransmitter or neuromodulator secreted by hypothalamic neurons. Its main function is to promote food intake and increase body weight. The mechanism by which orexin induces excessive feeding is related to the role of other appetite-regulating neuropeptides in the hypothalamus. This review summarizes the distribution of orexins and their receptors, and advances in their interactions with leptin, neuropeptide Y, corticotropin releasing factor, cocaine and amphetamine-regulated transcription factors, serotonin and so on