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日本东京消息:东京一研究小组报告,将包裹有前列腺素E_1(PGE_1)的微脂球置于炎症组织部位,可提高PGE_1作用10—20倍,且副作用降至最低。微脂球直径O.2μ,由豆油组成,覆以表面活性剂卵磷脂。圣玛丽安娜大学医学院内一科的研究人员在进行动物实验时发现,静脉内注入放射性同位素标记的微脂球可选择性地向炎症部位移动。保志庆幸博士对日本炎症协会说,这种脂质微球是经损伤部位血管壁内皮细胞间隙渗出的。保志等将PGE_1掺合到微脂球(内加环状糊精,做为稳定剂)。前列腺素有血管扩张作用,并可抑制血小板聚集,它广泛用于治疗外周血管病变。然而,前列腺素很容易失活、用量大,因而常导致低血压及血管性疼痛。研究人员报告了10名患者,5人患糖尿
TOKYO, Japan: A Tokyo-based research team reported that placing liposomes coated with prostaglandin E_1 (PGE_1) on the site of inflammatory tissue increases 10-20-fold PGE_1 effects with minimal side effects. Lipid diameter O. 2μ, composed of soybean oil, covered with surfactant lecithin. Researchers at a department of St. Mary’s University Medical School found in animal experiments that intravenous injection of radioisotope-labeled micro-liposomes can selectively move to the site of inflammation. Dr. Bao Zhiqing told the Japan Association of Inflammation that the lipid microspheres are exuded through the interstitial spaces of the blood vessel wall at the site of injury. Paul and other PGE_1 will be incorporated into the liposomes (plus cyclodextrin, as a stabilizer). Prostaglandins have vasodilator effects, and can inhibit platelet aggregation, which is widely used in the treatment of peripheral vascular disease. However, prostaglandins are easily inactivated and in large doses, and often cause hypotension and vascular pain. The researchers reported 10 patients and 5 had diabetes