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目的探讨新生儿感染性疾病中C反应蛋白、白细胞和中性粒细胞的变化及临床意义。方法 352例感染患儿中分为细菌感染组(195例)和病毒感染组(157例),另外选取健康足月儿140例作为正常对照组。所有患儿入院时检测CRP、WBC和GRAN。感染组经过治疗后,于72 h、168 h复查CRP、WBC和GRAN,观察三者的动态变化。结果入院时新生儿细菌感染组CRP、WBC和GRAN均较正常对照组和病毒感染组显著升高(P<0.01)。治疗72和168 h后,细菌感染组CRP、WBC和GRAN明显下降(P<0.01),而病毒感染组各指标变化不明显(P>0.05)。结论新生儿感染中CRP、WBC和GRAN是很好的鉴别细菌与病毒感染的诊断指标,对判断病情变化与疗效具有一定价值。
Objective To investigate the changes and clinical significance of C-reactive protein, leukocyte and neutrophil in neonatal infectious diseases. Methods A total of 352 infected children were divided into bacterial infection group (195 cases) and virus infection group (157 cases). Another 140 healthy full-term infants were selected as normal control group. All children were admitted to hospital for detection of CRP, WBC and GRAN. In the infected group, the CRP, WBC and GRAN were examined at 72 h and 168 h after treatment. The dynamic changes of the three groups were observed. Results The CRP, WBC and GRAN in neonates with bacterial infection at admission were significantly higher than those in normal control group and virus-infected group (P <0.01). After 72 and 168 h of treatment, CRP, WBC and GRAN in bacterial infection group were significantly decreased (P <0.01), while those in virus infection group did not change significantly (P> 0.05). Conclusions CRP, WBC and GRAN in neonatal infection are good diagnostic indicators for the identification of bacterial and viral infections and have certain value in judging the changes and curative effects of the disease.