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目的评价环酯红霉素干混悬剂对小儿急性呼吸道感染的疗效及不良反应。方法将急性呼吸道感染患儿63例随机分为A组(29例)和B组(34例)。A组予环酯红霉素干混悬剂口服,每次15 mg·kg-1,2次·d-1。B组予阿奇霉素干混悬剂口服,每次10 mg·kg-1,1次·d-1。对2组患儿的发热时间、临床表现进行随访观察,比较2组临床痊愈率、有效率及不良反应情况,并对结果进行统计学分析。结果 A组和B组痊愈率分别为51.72%和61.76%,2组比较差异无统计学意义(P>0.05)。A组和B组有效率分别为89.66%和88.24%,2组比较差异无统计学意义(P>0.05)。比较2组发热、咳嗽等变化,结果显示差异无统计学意义。仅A组1例患儿出现恶心、呕吐、食欲下降等胃肠道反应,但可耐受,未影响继续治疗。结论环酯红霉素干混悬剂治疗小儿急性呼吸道感染安全有效,与阿奇霉素干混悬剂的疗效无明显差异。
Objective To evaluate the efficacy and adverse reactions of cyclic erythromycin in suspension in children with acute respiratory infection. Methods 63 children with acute respiratory infection were randomly divided into group A (n = 29) and group B (n = 34). Group A was orally administered with erythromycin in suspension, 15 mg · kg-1, 2 times · d-1 each time. Group B was given azithromycin dry suspension orally, each time 10 mg · kg -1,1 times · d -1. The fever time and clinical manifestations in two groups were followed up. The clinical cure rate, effective rate and adverse reactions in two groups were compared, and the results were statistically analyzed. Results The cure rates of group A and group B were 51.72% and 61.76%, respectively. There was no significant difference between the two groups (P> 0.05). The effective rates of group A and group B were 89.66% and 88.24% respectively, there was no significant difference between the two groups (P> 0.05). Compared 2 groups of fever, cough and other changes, the results showed no significant difference. Only group A patients with nausea, vomiting, loss of appetite and other gastrointestinal reactions, but can be tolerated, did not affect the continued treatment. Conclusion Cyclophosphamide dry suspension is safe and effective for the treatment of acute respiratory infection in children, and there is no significant difference between the efficacy of azithromycin and dry suspension.