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体重3.7～3.9kg雌兔分成三组:(1)胆管造瘘给铅组(2只);(2)给铅未造瘘组(2只);(3)造瘘未给铅组(1只)。给铅动物以12mg/kg(相当于 2/3致死剂量)的四乙铅兔耳静脉注射,24小时后采样测定胆汁、肠内容物、脏器、血和尿中的总铅、三乙铅、二乙铅和无机铅的含量。 1.胆汁排铅情况:造瘘给铅组中,给药后24小时约8％给药剂量的铅由胆汁排出(其中胆囊胆汁约1％,胆管胆汁约7％)。胆汁总铅中约97％为二乙铅,无机铅约2％,三乙铅约0.1％。给药后6～12小时铅的总排出量最高。随时间增长,胆管胆
Female rabbits weighing 3.7-3.9 kg were divided into three groups: (1) biliary fistula to lead group (2); (2) lead to fistula group (2); (3) only). Lead was injected intravenously at a dose of 12 mg / kg (equivalent to a lethal dose of 2/3) to lead tetrazolium and 24 hours later samples were taken for determination of total lead, bilirubin, organ, blood and urine , Lead diphosphate and inorganic lead content. 1. Bile excretion of lead: fistula to the lead group, about 24 hours after administration of about 8% of the dose of lead excreted by the bile (gallbladder bile about 1%, about 7% of bile duct bile). Approximately 97% of total bile lead is diethyl lead, inorganic lead is about 2% and triethyl lead is about 0.1%. 6 to 12 hours after administration of lead the highest total discharge. With time, bile duct gallbladder